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Both red hair and pale skin are caused by recessive MC1R sequence variants, and are closely related. Have you ever wondered where the fashion for tanning came from? In mammals the relative proportions of phaeomelanin and eumelanin are regulated by melanocyte stimulating hormone MSHwhich acts via its receptor MC1Ron melanocytes, to increase the synthesis of eumelanin3,4 and the product of the agouti locus which antagonises this action5. Do all redheads have freckles? After all, I still have my spots of redness to futilely attempt to minimize, even when my entire face is sweating off my skull. In other words, how many people with very brown skin have blonde hair?

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Our experience with Pale Skin I personally struggled during my teen years when friends would wear skirts after they had got an amazing tan.

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In mammals the relative proportions of phaeomelanin and eumelanin are regulated by melanocyte stimulating hormone MSHwhich acts via its receptor MC1Ron melanocytes, to increase the synthesis of eumelanin3,4 and the product of the agouti locus which antagonises this action5. Why do many people desire to have pale skin? Red hair - Biochemistry and genetics: Eumelanin is photoprotective whereas phaeomelanin, because of its potential to generate free radicals in response to UVR2, may contribute to UV-induced skin damage. Care to join me? Stay in the Know - Subscribe to our Newsletter.

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